| dc.creator |
Costelli, Paola |
|
| dc.creator |
Carbó Carbó, Neus |
|
| dc.creator |
Tessitore, Luciana |
|
| dc.creator |
Bagby, Gregory J. |
|
| dc.creator |
López-Soriano, Francisco J. |
|
| dc.creator |
Argilés Huguet, Josep Ma. |
|
| dc.creator |
Baccino, Francesco M. |
|
| dc.date |
2009-05-14T10:14:17Z |
|
| dc.date |
2009-05-14T10:14:17Z |
|
| dc.date |
1993 |
|
| dc.date.accessioned |
2024-12-16T10:17:53Z |
|
| dc.date.available |
2024-12-16T10:17:53Z |
|
| dc.identifier |
0021-9738 |
|
| dc.identifier |
http://hdl.handle.net/2445/8263 |
|
| dc.identifier |
79740 |
|
| dc.identifier |
8254032 |
|
| dc.identifier.uri |
http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/6763 |
|
| dc.description |
Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved. |
|
| dc.format |
7 p. |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.publisher |
American Society for Clinical Investigation |
|
| dc.relation |
Reproducció del document publicat a http://dx.doi.org/doi:10.1172/JCI116897 |
|
| dc.relation |
Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789. |
|
| dc.rights |
(c) The American Society for Clinical Investigation, 1993 |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.source |
Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
|
| dc.subject |
Tumors |
|
| dc.subject |
Necrosi |
|
| dc.subject |
Músculs |
|
| dc.subject |
Tumor necrosis factor |
|
| dc.subject |
Skeletal muscle |
|
| dc.subject |
Protein turnover |
|
| dc.title |
Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model. |
|
| dc.type |
info:eu-repo/semantics/article |
|
| dc.type |
info:eu-repo/semantics/publishedVersion |
|