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| dc.creator | Labarca, Gonzalo | |
| dc.creator | Henríquez Beltrán, Mario | |
| dc.creator | Lamperti, Liliana | |
| dc.creator | Nova Lamperti, Estefania | |
| dc.creator | Sanhueza, Sergio | |
| dc.creator | Cabrera, Camilo | |
| dc.creator | Quiroga, Romina | |
| dc.creator | Antilef, Barbara | |
| dc.creator | Ormazábal, Valeska | |
| dc.creator | Zúñiga, Felipe | |
| dc.creator | Castillo, Daniela | |
| dc.creator | Horta, Gloria | |
| dc.creator | Enos, Daniel | |
| dc.creator | Lastra, Jaime | |
| dc.creator | González, Jessica | |
| dc.creator | Targa, Adriano | |
| dc.creator | Barbé Illa, Ferran | |
| dc.date | 2022 | |
| dc.date.accessioned | 2025-11-03T12:17:16Z | |
| dc.date.available | 2025-11-03T12:17:16Z | |
| dc.identifier | https://doi.org/10.3389/fmed.2022.884218 | |
| dc.identifier | 2296-858X | |
| dc.identifier | http://hdl.handle.net/10459.1/83668 | |
| dc.identifier.uri | http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/24348 | |
| dc.description | Objective: To determine the association between Obstructive Sleep Apnea (OSA) with long-term symptoms and inflammatory cytokines, exploring the changes between 4-months and 1-year after COVID-19 infection. Methods: We conducted an observational, prospective cohort study, including patients ≥18 years old with confirmed diagnosis of COVID-19 between April to July 2020. All participants underwent two clinical follow-up visits, the first at 4-months (Visit 1) and the second at 1 year, after SARS-CoV-2 infection (Visit 2). Plasma glucose, total cholesterol, HDL, and triglycerides. Regarding pulmonary function, spirometry and lung diffusion capacity tests were assessed. For mental and neurocognitive evaluation, a short-form (SF-12), Beck depression and Hospital-Anxiety depression questionnaires were conducted at both time-points, whereas the Montreal Cognitive assessment was conducted during the second follow-up. Regarding to sleep evaluation, Epworth Sleepiness Scale, Insomnia Severity index and STOP-BANG questionnaire were conducted. Additionally, a home sleep apnea test and 7-day wrist actigraphy were performed in all participants. Inflammatory cytokines were measured using an inflammatory cytokine bead array kit. p-values < 0.05 were considered statistically significant and statistical analyses were performed using R software. Results: A total of 60 patients were included in the first follow-up, from which 57 completed the second follow-up. The mean age was 46.4 years-old (SD ± 13.1) and 53.3% were male. 30% of cases reported mild COVID-19 infection, 28.3% with moderate illness, and 41.6% with severe illness. Moreover, 56.6% of them were admitted to the ICU. Regarding to metabolic values, the OSA group showed higher values of insulin resistance (IR) (27%), systolic blood pressure (SBP) 135.2 (±19.1), dyslipidemia (67.5%), total cholesterol 202.1 (±60.5), triglycerides 176.1 (±119.0) and HOMA-IR 9.0 (±18.8) in comparison with the non-OSA group. 1 year after COVID-19 infection, DLCO test remains abnormal in OSA patients (25% OSA vs. 3.6% non-OSA, p = 0.02). Finally, those participants with OSA who develop ARDS reported an adjusted OR 20.4 (95%-CI, 1.04-504) risk of neurocognitive impairment. Discussion: Among patients with previous COVID-19, OSA impact the development of incident glycemic, neurocognitive impairment, and abnormal functional pulmonary changes that persist up to 1 year since acute phase. | |
| dc.description | This study was supported by the Agencia Nacional de Investigación y Desarrollo (ANID, COVID1005), Chilean Government. GL declares funding for research by the American Academy of Sleep Medicine (AASM, 254-FP-21). JG, FB, and AT declare funded by ISCIII (CIBERESUCICOVID, COV20/00110). EN-L, SS, CC, RQ and BA were funded by Fondecyt 1211480 and COVID-19 Genomics Network (C19-GenoNet) ACT210085. Figure 1 was created with BioRender.com and Flow Cytometer was funded by EQM150061 (FONDEQUIP-ANID). | |
| dc.language | eng | |
| dc.publisher | Frontiers Media | |
| dc.relation | Reproducció del document publicat a: https://doi.org/10.3389/fmed.2022.884218 | |
| dc.relation | Frontiers in Medicine, 2022, vol. 9 | |
| dc.rights | cc-by (c) Authors 2022 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | COVID-19 | |
| dc.subject | Cytokines | |
| dc.subject | Neurocognitive impairment | |
| dc.subject | Obstructive sleep apnea | |
| dc.subject | Symptoms | |
| dc.title | Impact of Obstructive Sleep Apnea (OSA) in COVID-19 Survivors, Symptoms Changes Between 4-Months and 1 Year After the COVID-19 Infection | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |
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