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| dc.creator | Pérez-Holanda Fernández, Sergio | |
| dc.creator | Rodrigo, Luis | |
| dc.creator | Viñas Salas, Joan | |
| dc.creator | Piñol Felis, Carme | |
| dc.creator | Ildefonso, C. | |
| dc.date | 2006 | |
| dc.date.accessioned | 2025-11-03T12:17:16Z | |
| dc.date.available | 2025-11-03T12:17:16Z | |
| dc.identifier | 1130-0108 | |
| dc.identifier | http://hdl.handle.net/10459.1/49278 | |
| dc.identifier.uri | http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/24343 | |
| dc.description | Objective: to examine the effect of fecal absence on experimental colon carcinogenesis in both male and female rats. Material and methods: a total of 138 10-week-old Sprague- Dawley, male and female rats were divided into five groups: A) 20 rats, no treatment; B) 26 rats, colonic defunctionalization; C) 30 rats, 18 weekly doses of dimethylhydrazine (DMH), 21 mg/kg body weight each, from the beginning of the study; D) 20 rats, ethylen-diamine-tetraacetic acid for 18 weeks; and E) 42 rats, same surgical procedure as rats in group B plus DMH injections at the same doses as rats in group C. Animals were sacrificed after 25-27 weeks. Number of tumors, their location, and pathological findings were all compared between groups. Results: no tumors developed in the dimethylhydrazine-free groups. No differences were obtained either in number of tumors or tumors per rat for group C as compared to group E. Fecal absence was associated with smaller-sized tumors (p = 0.007), greater numbers of non-mucinous tumors (p = 0.00009), better differentiation (p = 0.0054), and lesser penetration into the wall (p = 0.015) for group E as compared to group C. In the dimethylhydrazine group, fecal absence altered the number of tumors developing in males as compared to female rats (p = 0.025). Moreover, this fecal absence showed no inhibitory effect on right colonic tumors (p = 0.0065). Conclusions: fecal absence alters the DMH-carcinogenic pattern in the defunctionalized colon when using an experimental model in both male and female rats. | |
| dc.language | eng | |
| dc.publisher | Sociedad Española de Patología Digestiva | |
| dc.publisher | Arán Ediciones | |
| dc.relation | Reproducció del document publicat a http://scielo.isciii.es/scielo.php?pid=S1130-01082006000900002&script=sci_arttext | |
| dc.relation | Revista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649 | |
| dc.rights | (c) Arán Ediciones, 2006 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Cancer | |
| dc.subject | Carcinogenesis | |
| dc.subject | Colon | |
| dc.title | Effect of defunctionalization on colon carcinogenesis in the rat | |
| dc.type | article | |
| dc.type | publishedVersion |
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