| dc.creator |
Pérez-Holanda Fernández, Sergio |
|
| dc.creator |
Rodrigo, Luis |
|
| dc.creator |
Viñas Salas, Joan |
|
| dc.creator |
Piñol Felis, Carme |
|
| dc.creator |
Ildefonso, C. |
|
| dc.date |
2006 |
|
| dc.date.accessioned |
2025-11-03T12:17:16Z |
|
| dc.date.available |
2025-11-03T12:17:16Z |
|
| dc.identifier |
1130-0108 |
|
| dc.identifier |
http://hdl.handle.net/10459.1/49278 |
|
| dc.identifier.uri |
http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/24343 |
|
| dc.description |
Objective: to examine the effect of fecal absence on experimental
colon carcinogenesis in both male and female rats.
Material and methods: a total of 138 10-week-old Sprague-
Dawley, male and female rats were divided into five groups: A) 20
rats, no treatment; B) 26 rats, colonic defunctionalization; C) 30
rats, 18 weekly doses of dimethylhydrazine (DMH), 21 mg/kg
body weight each, from the beginning of the study; D) 20 rats,
ethylen-diamine-tetraacetic acid for 18 weeks; and E) 42 rats,
same surgical procedure as rats in group B plus DMH injections at
the same doses as rats in group C. Animals were sacrificed after
25-27 weeks. Number of tumors, their location, and pathological
findings were all compared between groups.
Results: no tumors developed in the dimethylhydrazine-free
groups. No differences were obtained either in number of tumors
or tumors per rat for group C as compared to group E. Fecal absence
was associated with smaller-sized tumors (p = 0.007),
greater numbers of non-mucinous tumors (p = 0.00009), better
differentiation (p = 0.0054), and lesser penetration into the wall
(p = 0.015) for group E as compared to group C. In the dimethylhydrazine
group, fecal absence altered the number of tumors developing
in males as compared to female rats (p = 0.025). Moreover,
this fecal absence showed no inhibitory effect on right
colonic tumors (p = 0.0065).
Conclusions: fecal absence alters the DMH-carcinogenic pattern
in the defunctionalized colon when using an experimental
model in both male and female rats. |
|
| dc.language |
eng |
|
| dc.publisher |
Sociedad Española de Patología Digestiva |
|
| dc.publisher |
Arán Ediciones |
|
| dc.relation |
Reproducció del document publicat a http://scielo.isciii.es/scielo.php?pid=S1130-01082006000900002&script=sci_arttext |
|
| dc.relation |
Revista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649 |
|
| dc.rights |
(c) Arán Ediciones, 2006 |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.subject |
Cancer |
|
| dc.subject |
Carcinogenesis |
|
| dc.subject |
Colon |
|
| dc.title |
Effect of defunctionalization on colon carcinogenesis in the rat |
|
| dc.type |
article |
|
| dc.type |
publishedVersion |
|