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Portal hypertension in acute liver failure

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dc.creator Navasa, Miquel
dc.creator García Pagán, Juan Carlos
dc.creator Bosch i Genover, Jaume
dc.creator Riera, J. R.
dc.creator Bañares, Rafael
dc.creator Mas Comas, Ana M.
dc.creator Bruguera i Cortada, Miquel, 1942-
dc.creator Rodés, J.
dc.date 2011-07-07T12:30:59Z
dc.date 2011-07-07T12:30:59Z
dc.date 1992
dc.date.accessioned 2024-12-16T10:27:16Z
dc.date.available 2024-12-16T10:27:16Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18676
dc.identifier 88651
dc.identifier 1644339
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22175
dc.description Twenty five patients with acute liver failure were measured for hepatic venous pressure gradient as an index of portal pressure during the course of a transjugular liver biopsy. Hepatic venous pressure gradient ranged from 4 to 24.5 mm Hg with a mean of 12.8 (5.3) mm Hg (normal values less than 5 mm Hg). All patients but one had increased portal pressure gradient. Portal hypertension correlated with the degree of architectural distortion of the liver, as suggested by a direct correlation between hepatic venous pressure gradient and the area of reticulin collapse, evaluated by means of a morphometric analysis on Sirius red stained liver slides (r = 0.43, p less than 0.05). Hepatic venous pressure gradient was significantly higher in patients with ascites (15.1 (5) mm Hg, n = 15) or renal failure (14.4 (5.3) mm Hg, n = 16) than in those without (9.3 (3.4) mm Hg and 10.1 (4) mm Hg, respectively; p less than 0.05). Portal hypertension was associated with systemic vasodilation and a hyperkinetic circulatory state, with decreased arterial pressure, and peripheral resistance and increased cardiac output.
dc.format 4 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.33.7.965
dc.relation Gut, 1992, vol. 33, p. 965-968
dc.relation http://dx.doi.org/10.1136/gut.33.7.965
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1992
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Medicina)
dc.subject Hipertensió portal
dc.subject Malalties del fetge
dc.subject Fetge
dc.subject Portal hypertension
dc.subject Liver diseases
dc.subject Liver
dc.title Portal hypertension in acute liver failure
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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