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Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.

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dc.creator Rigopoulou, E. I.
dc.creator Davies, E. T.
dc.creator Parés Darnaculleta, Albert
dc.creator Zachou, K.
dc.creator Liaskos, C.
dc.creator Bogdanos, D. P.
dc.creator Rodés, J.
dc.creator Dalekos, G. N.
dc.creator Vergani, Diego
dc.date 2011-07-07T12:30:56Z
dc.date 2011-07-07T12:30:56Z
dc.date 2005
dc.date.accessioned 2024-12-16T10:27:16Z
dc.date.available 2024-12-16T10:27:16Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18674
dc.identifier 583556
dc.identifier 15753539
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22171
dc.description with specific ANA, in particular of the IgG3 isotype, had significantly more severe biochemical and histological disease compared with those who were seronegative. None of the controls was positive. Conclusions: Disease specific ANA are present in the majority of patients with PBC when investigated at the level of immunoglobulin isotype. PBC specific ANA, in particular of the IgG3 isotype, are associated with a more severe disease course, possibly reflecting the peculiar ability of this isotype to engage mediators of damage.
dc.format 5 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2003.036558
dc.relation Gut, 2005, vol. 54, núm. 4, p. 528-532
dc.relation http://dx.doi.org/10.1136/gut.2003.036558
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2005
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Medicina)
dc.subject Autoanticossos
dc.subject Malalties autoimmunitàries
dc.subject Cirrosi hepàtica
dc.subject Autoantibodies
dc.subject Autoimmune diseases
dc.subject Hepatic cirrhosis
dc.title Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis.
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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