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Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C

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dc.creator Arena, Umberto
dc.creator Vizzutti, Francesco
dc.creator Abraldes, Juan G.
dc.creator Corti, G.
dc.creator Stasi, C.
dc.creator Moscarella, S.
dc.creator Milani, S.
dc.creator Lorefice, E.
dc.creator Petrarca, A.
dc.creator Romanelli, R. G.
dc.creator Laffi, G.
dc.creator Bosch i Genover, Jaume
dc.creator Marra, F.
dc.creator Pinzani, Massimo
dc.date 2011-07-07T12:30:36Z
dc.date 2011-07-07T12:30:36Z
dc.date 2008
dc.date.accessioned 2024-12-16T10:27:15Z
dc.date.available 2024-12-16T10:27:15Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18660
dc.identifier 567042
dc.identifier 18448567
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22142
dc.description Background: Transient elastography (TE) has received increasing attention as a means to evaluate disease progression in patients with chronic liver disease. Aim: To assess the value of TE for predicting the stage of fibrosis. Methods: Liver biopsy and TE were performed in 150 consecutive patients with chronic hepatitis C-related hepatitis (92 men and 58 women, age 50.6 (SD 12.5) years on the same day. Necro-inflammatory activity and the degree of steatosis at biopsy were also evaluated. Results: The areas under the curve for the prediction of significant fibrosis (⩾F2), advanced fibrosis (⩾F3) or cirrhosis were 0.91, 0.99 and 0.98, respectively. Calculation of multilevel likelihood ratios showed that values of TE <6 or ⩾12, <9 or ⩾12, and <12 or ⩾18, clearly indicated the absence or presence of significant fibrosis, advanced fibrosis, and cirrhosis, respectively. Intermediate values could not be reliably associated with the absence or presence of the target condition. The presence of inflammation significantly affected TE measurements in patients who did not have cirrhosis (p<0.0001), even after adjusting for the stage of fibrosis. Importantly, TE measurements were not influenced by the degree of steatosis. Conclusions: TE is more suitable for the identification of patients with advanced fibrosis than of those with cirrhosis or significant fibrosis. In patients in whom likelihood ratios are not optimal and do not provide a reliable indication of the disease stage, liver biopsy should be considered when clinically indicated. Necro-inflammatory activity, but not steatosis, strongly and independently influences TE measurement in patients who do not have cirrhosis.
dc.format 7 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2008.149708
dc.relation Gut, 2008, vol. 57, núm. 9, p. 1288-1293
dc.relation http://dx.doi.org/10.1136/gut.2008.149708
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2008
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Medicina)
dc.subject Hepatitis C
dc.subject Ecografia
dc.subject Diagnòstic per la imatge
dc.subject Fetge
dc.subject Hepatitis C
dc.subject Ultrasonic imaging
dc.subject Diagnostic imaging
dc.subject Liver
dc.title Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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