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Low dose alpha interferon therapy can be effective in chronic active hepatitis C. Results of a multicentre, randomised trial

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dc.creator Forns, Xavier
dc.creator Ampurdanés, Sergi
dc.creator Titó Espinagosa, Llúcia
dc.creator Planas Vilà, Ramon
dc.creator Viver i Pi-Suñer, Josep M.
dc.creator Acero i Fernández, Doroteo
dc.creator Torres Salinas, Miguel
dc.creator Mas, P.
dc.creator Morillas Cunill, Rosa María
dc.creator Forné Bardera, Montserrat
dc.creator Espinós, J.
dc.creator Llovet i Bayer, Josep Maria
dc.creator Costa i Camps, Josep
dc.creator Olmedo Casas, Eva
dc.creator López Labrador, Francesc Xavier
dc.creator Jiménez de Anta Losada, María Teresa
dc.creator Rodés, J.
dc.creator Sánchez Tapias, José M. (José María)
dc.date 2011-07-07T12:30:17Z
dc.date 2011-07-07T12:30:17Z
dc.date 1996
dc.date.accessioned 2024-12-16T10:27:14Z
dc.date.available 2024-12-16T10:27:14Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18647
dc.identifier 153463
dc.identifier 8707096
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22114
dc.description BACKGROUND--There is some controversy concerning the efficacy of low dose alpha interferon therapy in chronic hepatitis C. AIMS--To evaluate the effectiveness of treatment with low doses of alpha interferon in chronic hepatitis C. PATIENTS--One hundred and forty one patients with anti-HCV positive chronic active hepatitis C from six hospitals were enrolled in the study. METHODS--Patients were randomised to treatment with 5 MU (group A) or 1.5 MU (group B) injections. The dose was reduced in responders from group A or increased in non-responders from group B to maintain treatment with the minimal effective dose. Patients were treated for 48 weeks and followed up for 24 additional weeks with no treatment. Normalisation of alanine aminotransferase (ALT) was used to evaluate response. RESULTS--A sustained response was seen in eight patients from group A (12%) and in 15 (21%) from group B. This difference was not statistically significant. Increasing the dose of interferon led to sustained response in only five of 58 patients (9%) from group B who did not respond to 1.5 MU injections. In contrast, 15 of 21 patients (71%) in whom ALT remained normal with 1.5 MU injections developed a sustained response. By multivariate analysis sustained response seemed associated with young age and was more frequent in patients with genotype 3 HCV infection. Sustained response was preceded by a rapid normalisation of ALT and was inversely related to the amount of alpha interferon necessary to maintain ALT at low values during treatment. CONCLUSIONS--Some patients with chronic hepatitis C are very sensitive to alpha interferon and can be successfully treated with low doses. Treatment with higher doses may be effective in a minority of patients who do not respond to low doses.
dc.format 7 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.38.4.603
dc.relation Gut, 1996, vol. 38, núm.4, p. 603-609
dc.relation http://dx.doi.org/10.1136/gut.38.4.603
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1996
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Medicina)
dc.subject Interferó
dc.subject Hepatitis C
dc.subject Terapèutica
dc.subject Assaigs clínics
dc.subject Interferon
dc.subject Hepatitis C
dc.subject Therapeutics
dc.subject Clinical trials
dc.title Low dose alpha interferon therapy can be effective in chronic active hepatitis C. Results of a multicentre, randomised trial
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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