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Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis

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dc.creator Clemente, C.
dc.creator Bosch i Genover, Jaume
dc.creator Rodés, J.
dc.creator Arroyo, Vicente
dc.creator Mas Comas, Ana M.
dc.creator Maragall, S.
dc.date 2011-07-07T12:30:09Z
dc.date 2011-07-07T12:30:09Z
dc.date 1977
dc.date.accessioned 2024-12-16T10:27:14Z
dc.date.available 2024-12-16T10:27:14Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18642
dc.identifier 22099
dc.identifier 301485
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22107
dc.description Forty-three patients with cirrhosis and ascites, 21 with normal renal function, 10 with a progressive functional renal failure (FRF), and 12 with a steady FRF, were investigated for the presence of endotoxaemia by the Limulus lysate test. Endotoxaemia was found in nine patients with FRF and in none of the 21 with normal renal function (P less than 0-01). A positive Limulus test was almost exclusively associated with a progressive FRF (eight of 10 patients) and all but one of them died. Renal function improved as endotoxaemia disappeared in the survivor. Endotoxaemia was also associated with haemorrhage due to acute erosions of the gastric mucosa, being present in six of the seven patients who had this complication. Intravascular coagulation was not found in any patient. The Limulus test was positive in the ascitic fluid in 18 of 21 patients tested, although only two of them had peritonitis. These results suggest that endotoxaemia may play a critical role in the development of progressive renal failure and haemorrhagic gastritis in cirrhosis, and emphasise the potential risk of procedures involving reinfusion of ascitic fluid.
dc.format 5 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.18.7.556
dc.relation Gut, 1977, vol. 18, núm. 7, p. 556-560
dc.relation http://dx.doi.org/10.1136/gut.18.7.556
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1977
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Medicina)
dc.subject Insuficiència renal aguda
dc.subject Cirrosi hepàtica
dc.subject Hemorràgia gastrointestinal
dc.subject Endotoxines
dc.subject Gastritis
dc.subject Hepatic cirrhosis
dc.subject Acute renal failure
dc.subject Gastritis
dc.subject Gastrointestinal hemorrhage
dc.subject Endotoxins
dc.title Functional renal failure and haemorrhagic gastritis associated with endotoxaemia in cirrhosis
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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