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Guidelines for the clinical management of familial adenomatous polyposis (FAP)

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dc.creator Vasen, Hans
dc.creator Möslein, Gabriela
dc.creator Alonso, A.
dc.creator Aretz, S.
dc.creator Bernstein, Inge
dc.creator Bertario, Lucio
dc.creator Blanco Guillermo, Ignacio
dc.creator Bülow, S.
dc.creator Burn, John
dc.creator Capellá, G. (Gabriel)
dc.creator Colas, Chrystelle
dc.creator Engel, Christoph
dc.creator Frayling, Ian M.
dc.creator Friedl, W.
dc.creator Hes, F. J.
dc.creator Hodgson, Shirley
dc.creator Järvinen, Heikki
dc.creator Mecklin, Jukka-Pekka
dc.creator Møller, Pål
dc.creator Myrhoi, T.
dc.creator Nagengast, F. M.
dc.creator Parc, Yann
dc.creator Phillips, R.
dc.creator Clark, Susan K.
dc.creator Ponz de Leon, Maurizio
dc.creator Renkonen Sinisalo, Laura
dc.creator Sampson, J. R.
dc.creator Stormorken, A.
dc.creator Tejpar, Sabine
dc.creator Thomas, H. J. W.
dc.creator Wijnen, Juul
dc.date 2011-07-07T11:33:24Z
dc.date 2011-07-07T11:33:24Z
dc.date 2008
dc.date.accessioned 2024-12-16T10:27:14Z
dc.date.available 2024-12-16T10:27:14Z
dc.identifier 0017-5749
dc.identifier http://hdl.handle.net/2445/18640
dc.identifier 559777
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/22105
dc.description Background: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for <1% of all colorectal cancer (CRC) cases. The syndrome is characterised by the development of hundreds to thousands of adenomas in the colorectum. Almost all patients will develop CRC if they are not identified and treated at an early stage. The syndrome is inherited as an autosomal dominant trait and caused by mutations in the APC gene. Recently, a second gene has been identified that also gives rise to colonic adenomatous polyposis, although the phenotype is less severe than typical FAP. The gene is the MUTYH gene and the inheritance is autosomal recessive. In April 2006 and February 2007, a workshop was organised in Mallorca by European experts on hereditary gastrointestinal cancer aiming to establish guidelines for the clinical management of FAP and to initiate collaborative studies. Thirty-one experts from nine European countries participated in these workshops. Prior to the meeting, various participants examined the most important management issues according to the latest publications. A systematic literature search using Pubmed and reference lists of retrieved articles, and manual searches of relevant articles, was performed. During the workshop, all recommendations were discussed in detail. Because most of the studies that form the basis for the recommendations were descriptive and/or retrospective in nature, many of them were based on expert opinion. The guidelines described herein may be helpful in the appropriate management of FAP families. In order to improve the care of these families further, prospective controlled studies should be undertaken.
dc.format 10 p.
dc.format application/pdf
dc.language eng
dc.publisher BMJ Group
dc.relation Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.2007.136127
dc.relation Gut, 2008, vol. 57, núm. 5, p. 704-713
dc.relation http://dx.doi.org/10.1136/gut.2007.136127
dc.rights (c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 2008
dc.rights info:eu-repo/semantics/openAccess
dc.source Articles publicats en revistes (Patologia i Terapèutica Experimental)
dc.subject Pòlips (Patologia)
dc.subject Intestins
dc.subject Malalties intestinals
dc.subject Polyps (Pathology)
dc.subject Intestines
dc.subject Intestinal diseases
dc.subject Medical protocols
dc.title Guidelines for the clinical management of familial adenomatous polyposis (FAP)
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion


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