| dc.contributor |
Ariza Piquer, Xavier |
|
| dc.creator |
Galindo Muñoz, Alex |
|
| dc.date |
2018-02-07T14:47:29Z |
|
| dc.date |
2018-02-07T14:47:29Z |
|
| dc.date |
2018-01 |
|
| dc.date.accessioned |
2024-12-16T10:26:09Z |
|
| dc.date.available |
2024-12-16T10:26:09Z |
|
| dc.identifier |
http://hdl.handle.net/2445/119663 |
|
| dc.identifier.uri |
http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/20595 |
|
| dc.description |
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2018, Tutor: Xavier Ariza Piquer |
|
| dc.description |
Obesity has become a priority health issue for many governments and organisations such as the WHO, it has gained the status of epidemic and according to the past years trends, the forecasts are not hopeful. The research for anti-obesity drugs has grown in the past years as the percentage of obese people grows globally. A relatively new anti-cancer drug (C75) was tested as anti-cancer drug to rodents, and it was observed that the specimens were showing an anorexigenic behaviour. The molecule was interacting in the hypothalamus reducing the food intake. Since this side effect was discovered many have been the attempts to find derivatives and analogues of C75 focusing on its food intake modulator basal.
In this project, we have focused on the synthesis of C75 analogue called (±)-UB-207 that was first reported in 2012. The novelty of the present work consists in modifying the initial synthetic route in order to simplify the obtainment of the pure derivative |
|
| dc.format |
43 p. |
|
| dc.format |
application/pdf |
|
| dc.language |
eng |
|
| dc.rights |
cc-by-nc-nd (c) Galindo, 2018 |
|
| dc.rights |
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
|
| dc.rights |
info:eu-repo/semantics/openAccess |
|
| dc.source |
Treballs Finals de Grau (TFG) - Química |
|
| dc.subject |
Inhibidors enzimàtics |
|
| dc.subject |
Obesitat |
|
| dc.subject |
Hipotàlem |
|
| dc.subject |
Àcids grassos |
|
| dc.subject |
Treballs de fi de grau |
|
| dc.subject |
Enzyme inhibitors |
|
| dc.subject |
Obesity |
|
| dc.subject |
Hypothalamus |
|
| dc.subject |
Fatty acids |
|
| dc.subject |
Bachelor's theses |
|
| dc.title |
Preparation of the enzymatic inhibitor UB-207 |
|
| dc.title |
Preparación del inhibidor enzimático UB-207 |
|
| dc.type |
info:eu-repo/semantics/bachelorThesis |
|