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Modelling spatiotemporal gradients of biomolecules on polyethylene glycol hydrogels

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dc.contributor Martínez Fraiz, Elena
dc.contributor Altay, Gizem
dc.creator Folch Eguren, Jordi
dc.date 2017-11-03T14:17:41Z
dc.date 2017-11-03T14:17:41Z
dc.date 2017-06
dc.date.accessioned 2024-12-16T10:25:50Z
dc.date.available 2024-12-16T10:25:50Z
dc.identifier http://hdl.handle.net/2445/117384
dc.identifier.uri http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/20095
dc.description Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2017, Tutores : Elena Martínez, Gizem Altay
dc.description The di usion of the stemness proteins Epidermal grow factor, R-spondin and Noggin (involved in the intestinal epithelial development) within a hydrogel material was simulated using COMSOL Multiphysics software. For the model, similar sized model proteins; Insulin, Carbonic Anhydrase and Bovine Serum Albumin were used. The steady state times and concentrations were determined at the gel surface for a rectangular and a pillar array model. It has been found that geometry was important and had to be implemented in order to better predict the surface concentrations. The gradient obtained along the pillar surface was most evident for BSA (Noggin). We believe that this model can be useful in designing experiments in intestinal epithelial development studies.
dc.format 5 p.
dc.format application/pdf
dc.language eng
dc.rights cc-by-nc-nd (c) Folch, 2017
dc.rights http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights info:eu-repo/semantics/openAccess
dc.source Treballs Finals de Grau (TFG) - Física
dc.subject Biomolècules
dc.subject Models matemàtics
dc.subject Treballs de fi de grau
dc.subject Biomolecules
dc.subject Mathematical models
dc.subject Bachelor's theses
dc.title Modelling spatiotemporal gradients of biomolecules on polyethylene glycol hydrogels
dc.type info:eu-repo/semantics/bachelorThesis


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