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| dc.creator | Carreras, Alba | |
| dc.creator | Rojas, Mauricio | |
| dc.creator | Tsapikouni, Theodora | |
| dc.creator | Montserrat Canal, José Ma. | |
| dc.creator | Navajas Navarro, Daniel | |
| dc.creator | Farré Ventura, Ramon | |
| dc.date | 2010-09-10T10:55:12Z | |
| dc.date | 2010-09-10T10:55:12Z | |
| dc.date | 2010-07-06 | |
| dc.date.accessioned | 2024-12-16T10:25:12Z | |
| dc.date.available | 2024-12-16T10:25:12Z | |
| dc.identifier | 1465-9921 | |
| dc.identifier | http://hdl.handle.net/2445/13645 | |
| dc.identifier | 584176 | |
| dc.identifier | 20604943 | |
| dc.identifier.uri | http://fima-docencia.ub.edu:8080/xmlui/handle/123456789/19007 | |
| dc.description | Background: The aim was to test the hypothesis that the blood serum of rats subjected to recurrent airway obstructions mimicking obstructive sleep apnea (OSA) induces early activation of bone marrow-derived mesenchymal stem cells (MSC) and enhancement of endothelial wound healing. Methods: We studied 30 control rats and 30 rats subjected to recurrent obstructive apneas (60 per hour, lasting 15 s each, for 5 h). The migration induced in MSC by apneic serum was measured by transwell assays. MSC-endothelial adhesion induced by apneic serum was assessed by incubating fluorescent-labelled MSC on monolayers of cultured endothelial cells from rat aorta. A wound healing assay was used to investigate the effect of apneic serum on endothelial repair. Results: Apneic serum showed significant increase in chemotaxis in MSC when compared with control serum: the normalized chemotaxis indices were 2.20 +- 0.58 (m +- SE) and 1.00 +- 0.26, respectively (p < 0.05). MSC adhesion to endothelial cells was greater (1.75 +- 0.14 -fold; p < 0.01) in apneic serum than in control serum. When compared with control serum, apneic serum significantly increased endothelial wound healing (2.01 +- 0.24 -fold; p < 0.05). Conclusions: The early increases induced by recurrent obstructive apneas in MSC migration, adhesion and endothelial repair suggest that these mechanisms play a role in the physiological response to the challenges associated to OSA. | |
| dc.format | 7 p. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | BioMed Central | |
| dc.relation | Reproducció del document publicat a http://dx.doi.org/10.1186/1465-9921-11-91 | |
| dc.relation | Respiratory Research 2010, 11:91, p. 1-7 | |
| dc.relation | http://dx.doi.org/10.1186/1465-9921-11-91 | |
| dc.rights | cc-by (c) Carreras et al., 2010 | |
| dc.rights | http://creativecommons.org/licenses/by/2.0 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Articles publicats en revistes (Ciències Fisiològiques) | |
| dc.subject | Trastorns respiratoris | |
| dc.subject | Fisiologia animal | |
| dc.subject | Respiration disorders | |
| dc.subject | Physiology, Comparative | |
| dc.title | Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion |
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