Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2017, Tutor: Manuel Martínez López
Thiosemicarbazones have been considered as antiviral, antibacterial, and antineoplastic agents in multiple studies through the years. Furthermore, their ability as excellent chelators for iron in its ferrous and ferric forms, make them very promising drugs in anti-cancer therapy from a polypharmacological perspective, as they can fight multiple molecular targets via iron deprivation and cell cytotoxicity.
By changing the structure of these chelating compounds the chemical properties of their Fe complexes can be altered and in turn, their biological activity. Having this in mind, studying the effects of structural changes via kinetic experimentation is essential to help in the design of future generations of thiosemicarbazones with enhanced properties by their own or their complexes.
The work here presented studies the oxidation of Fe(II) bis-thiosemicarbazone complexes from the ApT and DpT series by oxygen in solution from a kinetic perspective. The dependence of the reaction rate constant on different temperature and pressure for MeOH solutions and the effect of pH in aqueous solutions will be discussed. A basic mechanistic approach will also be used to interpret the kinetic and activation parameters obtained